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Original Article
Open Access
Dupilumab Effects on Innate Lymphoid Cell and Helper T Cell Populations in Patients with Atopic Dermatitis
JID Innovations
Vol. 1Issue 1100003Published online: February 19, 2021
- Yasutomo Imai
- Minori Kusakabe
- Makoto Nagai
- Koubun Yasuda
- Kiyofumi Yamanishi
Cited in Scopus: 0
Group 2 innate lymphoid cells (ILCs) are thought to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type 2 (Th2) cells and ILC2s to proliferate and produce cytokines. Dupilumab, an antibody against the IL-4 receptor, is used in AD therapy. We speculated that its efficacy might involve blocking the activation of Th2 cells and ILC2s via IL-4. Here, we examined circulating Th2 cells and ILC2s in 27 Japanese patients with AD before and after the administration of dupilumab.