March 2021 — Vol 1 No 1
The IF image shows a mitotic keratinocyte with NuMA, a protein required for orienting the spindle, in green, microtubules in red, and the condensed DNA is blue. The model shows some of the molecular machinery that promotes spindle orientation. NuMA (blue) is recruited to the cell cortex by LGN (green). NuMA both directly binds microtubules and recruits the dynein/dynactin complex (red) to generate the forces required to orient the mitotic spindle. Image credit: Terry Lechler, Duke University; illustration credit: Jan Ruvido Stebbins.