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      Open Access

      Cracking the Skin Barrier: Liquid-Liquid Phase Separation Shines under the Skin

      JID Innovations
      Vol. 1Issue 3100036Published online: July 5, 2021
      • Alexa Regina Chua Avecilla
      • Felipe Garcia Quiroz
      Cited in Scopus: 0
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        Central to forming and sustaining the skin’s barrier, epidermal keratinocytes (KCs) fluxing to the skin surface undergo a rapid and enigmatic transformation into flat, enucleated squames. At the crux of this transformation are intracellular keratohyalin granules (KGs) that suddenly disappear as terminally differentiating KCs transition to the cornified skin surface. Defects in KGs have long been linked to skin barrier disorders. Through the biophysical lens of liquid-liquid phase separation (LLPS), these enigmatic KGs recently emerged as liquid-like membraneless organelles whose assembly and subsequent pH-triggered disassembly drive squame formation.
        Cracking the Skin Barrier: Liquid-Liquid Phase Separation Shines under the Skin
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