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Cell Biology

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Original Article
Open Access
Determination of Chemical Irritation Potential Using a Defined Gene Signature Set on Tissue-Engineered Human Skin Equivalents
JID Innovations
Vol. 1Issue 2100011Published online: March 15, 2021
- Amy L. Harding
- Craig Murdoch
- Simon Danby
- Md Zobaer Hasan
- Hirofumi Nakanishi
- Tetsuo Furuno
- and others
Cited in Scopus: 0
There are no physical or visual manifestations that define skin sensitivity or irritation; a subjective diagnosis is made on the basis of the evaluation of clinical presentations, including burning, prickling, erythema, and itching. Adverse skin reaction in response to topically applied products is common and can limit the use of dermatological or cosmetic products. The purpose of this study was to evaluate the use of human skin equivalents based on immortalized skin keratinocytes and evaluate the potential of a 22-gene panel in combination with multivariate analysis to discriminate between chemicals known to act as irritants and those that do not.