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    • Original Article
      Open Access

      RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium

      JID Innovations
      Vol. 2Issue 5100139Published online: June 21, 2022
      • Luís C. Cabaço
      • Liliana Bento-Lopes
      • Matilde V. Neto
      • Andreia Ferreira
      • Wanja B.L. Staubli
      • José S. Ramalho
      • and others
      Cited in Scopus: 0
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        Skin pigmentation is imparted by melanin and is crucial for photoprotection against UVR. Melanin is synthesized and packaged into melanosomes within melanocytes and is then transferred to keratinocytes (KCs). Although the molecular players involved in melanogenesis have been extensively studied, those underlying melanin transfer remain unclear. Previously, our group proposed that coupled exocytosis/phagocytosis is the predominant mechanism of melanin transfer in human skin and showed an essential role for RAB11B and the exocyst tethering complex in this process.
        RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium
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