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Peripheral Blood Gene Expression Profile of Infants with Atopic Dermatitis
Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases

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Linoleic acid metabolites are found in both the free and total pools of fatty acids in human skin. Wheeler and co-workers show in Figure 1 a schematic depiction of Linoleic acid or oxylipins (i.e., 9,13-EHL and 9,10,13-THL) derived from LA, which are esterified into lipid membranes. The study suggests that free 9,10,13-THL and their analogs are potential pain mediators in mice and may be important in our understanding of pain and hypersensitivity associated with inflammatory skin diseases. See Wheeler et al, https://www.jidinnovations.org/article/S2667-0267(22)00085-6/fulltext.

Cover 1

The IF image shows a mitotic keratinocyte with NuMA, a protein required for orienting the spindle, in green, microtubules in red, and the condensed DNA is blue. The model shows some of the molecular machinery that promotes spindle orientation. NuMA (blue) is recruited to the cell cortex by LGN (green). NuMA both directly binds microtubules and recruits the dynein/dynactin complex (red) to generate the forces required to orient the mitotic spindle. Image credit: Terry Lechler, Duke University; illustration credit: Jan Ruvido Stebbins.

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Cover 2

The label-free photoacoustic microscopy image shows the dense microvasculature in a nude mouse ear bearing a xenografted B16 melanoma tumor. Hemoglobin in erythrocytes and melanin in melanocytes provide the imaging contrast for the blood vessels and melanoma tumor, respectively. Note that there is a principal artery-vein pair feeding and draining the tumor region. Depth is coded from blue (superficial) to red (deep). See full details in the article by Yao et al.

Cover 3

Liquid-liquid phase separation (LLPS) dynamics in skin. LLPS-driven assembly and disassembly of keratohyalin granules (KGs; cyan) play a prominent role throughout epidermal stratification. As cells move through the granular layer, KGs grow in number and volume, and become closely associated with keratin bundles as they crowd the cytoplasm. Abrupt intracellular acidification (granular layer; top right) initiates KG disassembly to actuate rapid enucleation and corneocyte formation. Defective KG-phase dynamics are linked to skin barrier disorders. For detail see the article by Avecilla and Quiroz.

Meet the Editor

Russell P. Hall, III, MD

Russell P. Hall, III, MD
J. Lamar Callaway Professor
Department of Dermatology
Duke University School of Medicine

Call for Submissions

JID Innovations invites submission of original scientific articles, clinical trial reports, case reports and case series, descriptions of methods and new technologies, reviews, and letters to the Editor. Areas of interest include all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases.

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Guide for Authors

Welcome to JID Innovations

Skin Science from Molecules to Population Health

The gold open access journal of the SID and ESDR

Now accepting submissions and publishing bimonthly

Meet the Editorial Board

JID Innovations News

New open access, peer-reviewed, online-only journal to serve the needs of the global dermatology community (September 29, 2020)

View the complete news release [pdf]

About

JID Innovations

Cover Image - JID Innovations, Volume 3, Issue 2

JID Innovations is an online-only Open Access journal that provides an international forum for the rapid and open publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. JID Innovations articles should address questions that are important and relevant to the community of researchers and clinicians focused on skin biology and disease. Submissions may confirm or challenge current knowledge, inform the community of a new technology or resource, advance a new hypothesis, or challenge existing paradigms (Read Dr Hall's editorial in JID). JID Innovations is dedicated to the free dissemination of these reports immediately upon publication, to all scientists and clinicians throughout the world, in order to more quickly advance our understanding of cutaneous biology, skin disease, and treatment.

JID Innovations invites submission of original scientific articles, clinical trial reports, case reports and case series, descriptions of methods and new technologies, reviews, and letters to the Editor.

JID Innovations Aims & Scope
JID Innovations FAQs
Meet the JID Innovations Editorial Board

Society for Investigative Dermatology (SID)

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

European Society for Dermatological Research (ESDR)

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.

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